PROBLEM TO BE SOLVED : To solve such a problem that although prevention of diseases and ageing can be expected by promoting activity of an oxidized protein hydrolase (OPH), there is a small number of substances known as active substances promoting the OPH activity.SOLUTION : An OPH activity enhancer comprises a combination including one or more extracts of burdock, oolong tea, roasted tea, lemongrass, Aloe arborescens, Sasa veitchii, pepper, Horduem vulgare, Gynostemma pentaphyllum, Gymnema sylvestre, Senna obtusifolia, Carthamus tinctorius, mulberry, Ganoderma lucidum, pu-erh tea, coarse tea, Houttuynia cordata, Coix lacryma-jobi var. frumentacea, and Senna occidentalis; and activates the oxidation proteolytic activity of oxidation proteolytic hydrolase (OPH) by 1.2 times or more.