A series of inventions refers to biotechnology, pharmaceutics, medicine, cosmetology, veterinary and can be used for prevention and treatment of bacterial and viral diseases in humans and animals, and also relates to the production of a wide range of sanitary and medicinal products. A thermostable composition with antiviral and antimicrobial activity and its use as a biologically active component for the production of sanitary and hygienic products as well as for protection from bacterial and viral infections has been claimed. In particular, the thermostable composition is a lyophilized powder containing the following components per 1 g of the composition : recombinant interferon gamma human with the activity from 500, 000 to 2, 000, 000 IU / g 0.03 to 0.12 mg lysostaphin with the activity from 50 to 200 U / g 0.17 to 0.68 mg methoxy polyethylene glycol 30 - 150 mg sodium alginate 10 - 25 mg sodium dihydrophosphate dihydrate 120 - 250 mg citric acid 35-110 mg dextran q.s.The proposed thermostable composition can be used as a component of oral cavity care products, toothpastes, sanitary-hygienic products, a clothes conditioner and condom lubricant and in a number of medicinal products and drugs.