As represented by formula I, a glycopeptide antibiotic compound having anti-drug-resistant bacteria activity or a pharmaceutically acceptable salt of same, a pharmaceutical preparation of same, a preparation method for same, and applications thereof. The compound of formula I has enhanced inhibitory activity against drug-resistant strains, particularly methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE), and is applicable in preparing a medicament for treating or preventing various diseases induced by bacterial infection such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.