PROBLEM TO BE SOLVED : To provide a platform technology for controlled oral delivery formulation of enhanced probiotics that specifically target to release in the pH environment of the ileum and the colon, for treatment/cure of various diseases. SOLUTION : The present invention relates to the development of a targeted delivery system for the oral delivery of a probiotic or a therapeutic agent for various indications, including and not limited to active and prophylaxis treatment of Clostridium difficile infection, antibiotic associated diarrhea, irritable bowel syndrome, Crohn' s disease, intestinal flora replacement, supplemental flora treatments for patients taking antibiotics, and for restoration of balance and signaling between the intestinal microbiome and the intestinal cells in patients under treatment of metabolic syndrome manifestations, specifically diabetes, insulin resistance, obesity, hyperlipidemia and hypertension. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT