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专利概况
专利名称 MACROCYCLES WITH AROMATIC P2' GROUP AS FACTOR XIA INHIBITORS
申请号 JP2019000516 申请日
公开(公告)号 JP2019077704A 公开(公告)日
申请(专利权)人 BRISTOL MYERS SQUIBB COMPANY 发明人 JAMES R CORTE; INDAWATI DLUCCA; FANG TIANAN; YANG WU; WANG YUFENG; ANDREW K DILGER; KUMAR BALASHANMUGA PABBISETTY; WILLIAM R EWING; ZHU YEHENG; RUTH R WEXLER; DONALD J P PINTO; MICHAEL J ORWAT; LEON M SMITH II
专利来源 国家知识产权局 转化方式
摘要

PROBLEM TO BE SOLVED : To provide a pharmaceutical composition comprising a macrocyclic compound or analog thereof being an inhibitor of factor XIa or a dual inhibitor of factor XIa and plasma kallikrein. SOLUTION : The invention relates to a pharmaceutical composition comprising a macrocyclic compound represented by (10R, 14S)-14-{4-[5-chloro-2-(4-chloro-1H-1, 2, 3-triazol-1-yl)phenyl]-6-oxo-1, 6-dihydropyrimidin-1-yl}-10-methyl-9-oxo-8, 16-diazatricyclo[13.3.1.02, 7]nonadeca-1(19), 2(7), 3, 5, 15, 17-hexaen-4, 5-dicarbonitrile, and a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, where the active ingredient is present in an amount of 0.1-95 wt.% based on the total weight of the pharmaceutical composition. The invention also relates to methods for treating thromboembolic and/or inflammatory disorders using the same. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT

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