专利名称 | Substituted hydroxamic acid compounds | ||
申请号 | JP2018224004 | 申请日 | |
公开(公告)号 | JP2019077688A | 公开(公告)日 | |
申请(专利权)人 | UNIV DUKE; UNIV OF NORTH CAROLINA | 发明人 | ZHOU PEI; ERIC J TOONE; ROBERT A NICHOLAS |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
PROBLEM TO BE SOLVED : To provide substituted hydroxamic acid compounds, and in particular, UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine deacetylase (LpxC), and methods of using such compounds to treat Gram-negative bacteria infections.SOLUTION : There are disclosed compounds of formulas (I) and (II), and pharmaceutically acceptable salts thereof, where the variables, R, R1, R2, R3, R21, R22, R23, R34, R37, R33, R39, D, Q, Y, X, X1, X3 and X4 are defined herein. These compounds are useful for treating Gram-negative bacteria infections.SELECTED DRAWING : NoneCOPYRIGHT : (C)2019, JPO&INPIT |
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