PROBLEM TO BE SOLVED : To solve the problem that although the relationship between peretinoin that has been reported to have anti-cancer action and anti-cancer activity is reported, a target substance thereof is not clear, and it has been difficult to lead to effective anti-cancer treatment.SOLUTION : Provided is a medicine for preventing the onset and recurrence of cancer which contains polyprenoic acid (PA) or a pharmaceutically acceptable salt or solvate thereof as an active ingredient, the medicine targeting cancer with HNF4α-expressing cells.SELECTED DRAWING : NoneCOPYRIGHT : (C)2019, JPO&INPIT