The invention provides sulfoxyalkyl organonitro and related compounds compositions containing such compounds and methods for using such compounds and compositions to treat medical disorders such as a neurodegenerative disorder autoimmune disease infection or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(33-dinitroazetidin-l-yl)-2- oxoethyl)sulfinyl)-D-alanine and variants thereof.