The present invention relates to the field of biomedicine and discloses a naphthyridine compound a pharmaceutical composition and use thereof. The naphthyridine compound has a structure as represented by formula (I) or in the form of a stereoisomer a geometric isomer a tautomer an oxynitride a hydrate a solvate a metabolite and a pharmaceutically acceptable salt or prodrug thereof. The naphthyridine compound of the present invention has significantly better anti-tumor effects than those in the prior art and the naphthyridine compound of the present invention can be used to treat protein kinase-mediated diseases.