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专利概况
专利名称 L-proline complex of sodium-glucose cotransporter 2 inhibitor, monohydrate and crystal form thereof
申请号 US15514118 申请日
公开(公告)号 US10301344B2 公开(公告)日
申请(专利权)人 Jiangsu Hengrui Medicine Co Ltd 发明人 Piaoyang Sun; Guaili Wu; Changshan Guo; Yun Lu; Yuxia Wu; Lingjia Shen
专利来源 国家知识产权局 转化方式
摘要

Provided are an L-proline complex of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline complex. Specifically, provided are 1, 6-dehydrated-1-C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl]phenyl}-5-C-(hydroxymethyl)-β-L-idopyranose L-proline (a compound of formula (I)), a monohydrate and a type A crystal thereof, and a preparation method therefor. The obtained type A crystal of the compound of formula (I) has good chemical stability and crystal stability, and the crystallization solvent used has low toxicity and low residue, so the type A crystal can be better used in clinical treatment.

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