The invention relates to the field of medicine, namely to apparatuses for the detection of tissue anomaly in a biological subject, and can be used for non-invasive early detection of cancer development risk.The tissue anomaly detection apparatus comprises a probe transmitter device structured to radiate a radio-frequency signal to irradiate a patient tissue in near-field conditions. Said probe transmitter device is provided with an antenna radiating element (12) configured to radiate the radio-frequency signal with a linear polarization and an actuator (13) mechanically coupled to the antenna radiating element (12) to cause a rotation of the antenna radiating element so as to rotate the polarization of the radio-frequency signal. The apparatus also comprises a control module (17) configured to send control signals to the actuator (13) to perform a rotation of the antenna radiating element (12) and of the linear polarization according to a pre-established angle.