The invention relates to molecular biology biotechnology medicine veterinary science. A group of inventions is proposed : a fusion protein comprising a ligand to MATN1 protein and a growth factor of EGF TGF FGF IGF the construct components are connected via a flexible link characterized by the amino acid sequence of Fig. 1; such fusion protein further comprising the Fc-fragment of an antibody or a polypeptide binding with FcRn and/or transferrin or a fragment thereof the construct components connected via a flexible link characterized by the amino acid sequence of Fig. 1; encoding polynucleotide codon-optimized for expression in the producer cells or a target organism a genetic construct for the synthesis of the fusion protein in producer cells or cells of a target organism the fusion protein producer a producer of a genetic construct based on a bacterial cell a preparation for the regeneration of cartilage containing at least 1 fusion protein or genetic construct as the active agent in an effective amount and a physiologically acceptable carrier or buffer solution for parenteral or in the case of the preparation based on at least 1 fusion protein containing the transport domain -oral administration in the latter case the preparation is enclosed in an enteric coating all -variants.