本发明系关於一种N-(6-(((2R, 3S)-3, 4-二羟基丁烷-2-基)氧基)-2-((4-氟苄基)硫基)嘧啶-4-基)-3-甲基氮杂环丁烷-1-磺醯胺(化合物4)，一种已知趋化因子调节剂，其与秋水仙硷组合可用於治疗其中可因调节趋化因子受体活性、介白素-1 (IL-1)活性及/或髓过氧化物酶(MPO)活性而受益的疾病/病状特定言之，本文中提供治疗及预防此等疾病/病状之组合物及方法; 化合物4 N-(6-(((2R, 3S)-3, 4-dihydroxy butan-2-yl)oxy)-2-((4-fluoro benzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide (compound 4), a known chemokine modulator, in combination with colchicine is useful in the treatment of diseases/conditions in which modulation of chemokine receptor activity, interleukin-1 (IL-1) activity, and/or myeloperoxidase (MPO) activity is beneficial. In particular, provided herein are compositions and methods for the treatment and prevention of such diseases/conditions.; Compound 4