The present invention relates to an ischemic brain disease resistant animal model and a method for producing the same. The ischemic brain disease resistant animal model of the present invention exhibits resistance due to double deletion of DAPK1 and Pin1 genes, and thus may be utilized for screening for test substances related to ischemic brain diseases, compared to conventional animal models susceptible to ischemic brain disease. Further, the ischemic brain disease resistant animal model may be used for reference in gene expression studies related to ischemic brain diseases, thereby being utilized in related pharmaceutical fields.COPYRIGHT KIPO 2019