专利名称 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES | ||
申请号 | WOEP18082537 | 申请日 | |
公开(公告)号 | WO2019105886A1 | 公开(公告)日 | |
申请(专利权)人 | GALAPAGOS NV | 发明人 | ALVEY Luke Jonathan; ANNOOT Denis Maurice; BONNATERRE Florence Marie Emilie; BUCHER Denis; DUTHION B閞anger; JARY H閘鑞e; PEIXOTO Christophe; TEMAL LAIB Taoues; TIRERA Amynata |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention discloses compounds according to Formula (I) : wherein R1, R2, R3a, R3b, X, Y1, Y2, Y3, and Z are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of TNFα, interferons, IL-6, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention. |
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