专利名称 | LONG LIFE POLYPEPTIDE BINDING MOLECULES | ||
申请号 | US16126617 | 申请日 | |
公开(公告)号 | US20190169295A1 | 公开(公告)日 | |
申请(专利权)人 | AMGEN RESEARCH (MUNICH) GMBH | 发明人 | Peter Kufer; Tobias Raum; Ralf Lutterb黶e; Markus M黱z; Johannes Brozy; Majk Kvesic; Patrick Hoffmann |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to a binding molecule comprising at least three domains comprised in at least one polypeptide chain, wherein the first binding domain is a binding domain which is capable of binding to a cell surface molecule on a target cell, the second binding domain is a binding domain which is capable of binding to the T cell CD3 receptor complex, and the third domain is a binding domain which is capable of binding to serum albumin, wherein said third domain is positioned at the C-terminus of said second domain. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule. |
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