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专利概况
专利名称 LONG LIFE POLYPEPTIDE BINDING MOLECULES
申请号 US16126617 申请日
公开(公告)号 US20190169295A1 公开(公告)日
申请(专利权)人 AMGEN RESEARCH (MUNICH) GMBH 发明人 Peter Kufer; Tobias Raum; Ralf Lutterb黶e; Markus M黱z; Johannes Brozy; Majk Kvesic; Patrick Hoffmann
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to a binding molecule comprising at least three domains comprised in at least one polypeptide chain, wherein the first binding domain is a binding domain which is capable of binding to a cell surface molecule on a target cell, the second binding domain is a binding domain which is capable of binding to the T cell CD3 receptor complex, and the third domain is a binding domain which is capable of binding to serum albumin, wherein said third domain is positioned at the C-terminus of said second domain. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

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