| 专利名称 | Delayed release oral tamsulosin hydrochloride | ||
| 申请号 | JP2018557863 | 申请日 | |
| 公开(公告)号 | JP2019514958A | 公开(公告)日 | |
| 申请(专利权)人 | アスペン パーク ファーマシューティカルズ インコーポレイティド | 发明人 | ケイ ガリー バーネット; ルース イー スティーブンス; ケネス ブイ フェルプス; リン ゴールド |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention relates in certain embodiments to a controlled release formulation, especially a sachet, comprising a unit dosage of a dry powder of tamsulosin or a pharmaceutically acceptable salt thereof in a controlled release matrix and to methods of making and using such formulation. The controlled release formulation is beneficial in the treatment of benign prostatic hyperplasia (BPH), particularly in those patients suffering from dysphagia. The controlled release formulation is easily dispersed in water or other suitable liquid, and so solves the problem of dysphagia, thereby improving patient compliance in that targeted patient population, yet the controlled release formulation has a release profile in a patient on an empty stomach similar to FLOMAX? ((R)-5-(2-{[2-(2-Ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide hydrochloride) taken 30 minutes after a meal, but does not exhibit the FLOMAX? tablet food effect, thereby improving dosage form administration flexibility. |
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