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专利概况
专利名称 2, 4 - Diamino - substituted quinoline derivatives used for treatment of diseases
申请号 JP2018557419 申请日
公开(公告)号 JP2019514951A 公开(公告)日
申请(专利权)人 ジェノシアンス ファルマ 发明人 ソニア ブラン; アントワーヌ ベレ; フィラ バシッシ; フィリップ アルフォン; ジェローム クールカンベク
专利来源 国家知识产权局 转化方式
摘要

This application discloses compounds according to generic Formula I : wherein all variables are defined as described herein which exhibit strong inhibition effects on various cancer cell lines. The compounds disclosed herein are useful for the treatment of proliferative diseases, including neoplastic diseases such as cancer and non-neoplastic disorders such as rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing compounds of Formula I and at least one carrier, diluent or excipient and optionally one or more additional therapeutically active agents, including anticancer agents. This application also discloses methods for treating a proliferative disease, including neoplastic diseases such as cancer and non-neoplastic disorders such as rheumatoid arthritis.

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