专利名称 | SOLID DOSAGE FORM CONTAINING SORAFENIB TOSYLATE | ||
申请号 | WOIB18001009 | 申请日 | |
公开(公告)号 | WO2018211336A3 | 公开(公告)日 | |
申请(专利权)人 | ALVOGEN MALTA OPERATIONS (ROW) LTD | 发明人 | ABRAHAM Mohit Jaya; YOGESH S Gattani; FANG He Yen; LAI Chieh Shan |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The invention relates to a solid dosage form containing Sorafenib tosylate which is used in pharmacy and medicine. An advantage of the composition according to the invention is improved bioavailability and tolerability, possibility of its applicable at lower optimal therapeutic doses that created balance between reduction of adverse drug reactions and abilility to overcome acquired resistance in the course of therapy. A solid dosage form, according to the invention, comprising Sorafenib tosylate, a precipitation inhibitor in an amount of 0.5 to 25% by weight, preferably from 0.5% to 15%, and most preferably from 1% to 10% and optionally other excipients. |
主管部门:海南中小企业服务 | 建设单位:海南商业联合会
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