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专利概况
专利名称 SOLID DOSAGE FORM CONTAINING SORAFENIB TOSYLATE
申请号 WOIB18001009 申请日
公开(公告)号 WO2018211336A3 公开(公告)日
申请(专利权)人 ALVOGEN MALTA OPERATIONS (ROW) LTD 发明人 ABRAHAM Mohit Jaya; YOGESH S Gattani; FANG He Yen; LAI Chieh Shan
专利来源 国家知识产权局 转化方式
摘要

The invention relates to a solid dosage form containing Sorafenib tosylate which is used in pharmacy and medicine. An advantage of the composition according to the invention is improved bioavailability and tolerability, possibility of its applicable at lower optimal therapeutic doses that created balance between reduction of adverse drug reactions and abilility to overcome acquired resistance in the course of therapy. A solid dosage form, according to the invention, comprising Sorafenib tosylate, a precipitation inhibitor in an amount of 0.5 to 25% by weight, preferably from 0.5% to 15%, and most preferably from 1% to 10% and optionally other excipients.

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