PROBLEM TO BE SOLVED : To provide pharmaceutical compositions suitable for anesthesiological applications that can achieve positive patient outcomes while free of drawbacks and deficiencies of existing methods and formulations.SOLUTION : The present invention relates to a pharmaceutical composition for anesthesiological applications in ophthalmic surgeries, the pharmaceutical composition comprising : (a) a first pharmacologically active compound selected from the group consisting of midazolam, diazepam, lorazepam, flunitrazepam, alprazolam, chlordiazepoxide, clonazepam, and clorazepate, and pharmaceutically acceptable salts, hydrates, solvates, and N-oxides thereof; (b) a second pharmacologically active compound selected from the group consisting of ketamine, dextrorphan, etomidate, methadone, memantine, amantadine, and dextromethorphan, and pharmaceutically acceptable salts, hydrates, solvates, and N-oxides thereof; (c) a binder; and (d) optionally, at least one excipient, the pharmaceutical composition being formulated as a solid item suitable for sublingual administration.SELECTED DRAWING : NoneCOPYRIGHT : (C)2019, JPO&INPIT