您好,欢迎来到海南中小企业大数据中心及公共服务平台!     请登录   免费注册
专利概况
专利名称 MODIFIED T LYMPHOCYTES
申请号 JP2019027075 申请日
公开(公告)号 JP2019088324A 公开(公告)日
申请(专利权)人 CELGENE CORP 发明人 STEWART ABBOT; LI TIANJIAN; LIANG BITAO
专利来源 国家知识产权局 转化方式
摘要

PROBLEM TO BE SOLVED : To provide modified T lymphocytes for treating diseases, such as cancer.SOLUTION : Provided is a T lymphocyte comprising an artificial cell death polypeptide comprising an apoptosis-inducing domain, the artificial cell death polypeptide being a transmembrane protein comprising an extracellular domain comprising a CD20 epitope, a transmembrane domain, and an intracellular domain comprising the apoptosis induction domain, the apoptosis induction domain being caspase 3, caspase 8 or caspase 9, the polypeptide being capable dimerization using an anti-CD20 antibody which binds to the CD20 epitope, and an apoptosis induction signal being generated in the T lymphocytes when the antibody dimerizes the polypeptide.SELECTED DRAWING : NoneCOPYRIGHT : (C)2019, JPO&INPIT

参与列表

主管部门:海南中小企业服务 | 建设单位:海南商业联合会

版权所有:海南商业联合会 | 备案号:粤ICP备13083911号(ICP加挂服务)@2017