专利名称 | MODIFIED T LYMPHOCYTES | ||
申请号 | JP2019027075 | 申请日 | |
公开(公告)号 | JP2019088324A | 公开(公告)日 | |
申请(专利权)人 | CELGENE CORP | 发明人 | STEWART ABBOT; LI TIANJIAN; LIANG BITAO |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
PROBLEM TO BE SOLVED : To provide modified T lymphocytes for treating diseases, such as cancer.SOLUTION : Provided is a T lymphocyte comprising an artificial cell death polypeptide comprising an apoptosis-inducing domain, the artificial cell death polypeptide being a transmembrane protein comprising an extracellular domain comprising a CD20 epitope, a transmembrane domain, and an intracellular domain comprising the apoptosis induction domain, the apoptosis induction domain being caspase 3, caspase 8 or caspase 9, the polypeptide being capable dimerization using an anti-CD20 antibody which binds to the CD20 epitope, and an apoptosis induction signal being generated in the T lymphocytes when the antibody dimerizes the polypeptide.SELECTED DRAWING : NoneCOPYRIGHT : (C)2019, JPO&INPIT |
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