Present invention provides a pharmaceutical for the prophylaxis or treatment of hypertension or a disease derived from hypertension. The pharmaceutical is characterized by administering (i) a specific mineralocorticoid receptor antagonist and (ii) one or more components selected from the following components (A) to (C) simultaneously or separately at a time interval : (A) an angiotensin II receptor antagonist, (B) a calcium antagonist, and (C) a diuretic.