| 专利名称 | OLIGONUCLEOTIDES FOR MODULATING RB1 EXPRESSION | ||
| 申请号 | WOEP18084077 | 申请日 | |
| 公开（公告）号 | WO2019115417A2 | 公开（公告）日 | |
| 申请（专利权）人 | ROCHE INNOVATION CENTER COPENHAGEN A/S | 发明人 | HAGEDORN Peter; PEDERSEN Lykke |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention relates to antisense oligonucleotides that are capable of modulating expression of RB1 in a target cell. The oligonucleotides hybridize to RB1 pre-mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment neurological injury or neuronal degeneration using the oligonucleotide. |
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