| 专利名称 | COMBINED USE OF IMMUNE EFFECTOR CELLS AND RADIATION THERAPY FOR TREATMENT OF TUMORS | ||
| 申请号 | WOCN18120593 | 申请日 | |
| 公开(公告)号 | WO2019114751A1 | 公开(公告)日 | |
| 申请(专利权)人 | CARSGEN THERAPEUTICS CO LTD; SHANGHAI CANCER INSTITUTE | 发明人 | LI Zonghai; ZHOU Min |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention relates to a combined use of immune effector cells and radiation therapy for the treatment of tumors. Specifically provided is a method for administering a combined use of immune effector cells and local tumor radiation therapy to an individual suffering from a tumor to perform treatment, and performing lymphodepletion on the individual; the immune effector cells comprise a tumor antigen that recognizes a tumor and a receptor that triggers the activation of the immune effector cells. The following has been confirmed by means of tests : the method for treating tumors as provided by the present invention improves the anticancer effect for cancer patients that are non-susceptible to CAR-T treatment or that have relapsed after treatment, and also improves anticancer therapeutic effects for cancer patients, such as the elimination of tumors and the prolonging of lifespan. |
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