专利名称 | MACROCYCLES WITH HETEROCYCLIC P2' GROUPS AS FACTOR XIA INHIBITORS | ||
申请号 | JP2019060181 | 申请日 | |
公开(公告)号 | JP2019094354A | 公开(公告)日 | |
申请(专利权)人 | BRISTOL MYERS SQUIBB COMPANY | 发明人 | JAMES R CORTE; INDAWATI DLUCCA; FANG TIANAN; YANG WU; WANG YUFENG; ANDREW K DILGER; KUMAR BALASHANMUGA PABBISETTY; WILLIAM R EWING; ZHU YEHENG; RUTH R WEXLER; DONALD J P PINTO; MICHAEL J ORWAT; LEON M SMITH II |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
PROBLEM TO BE SOLVED : To provide novel macrocyclic compounds, and analogues (including stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates) thereof, which are useful as selective factor XIa inhibitors or dual inhibitors of factor XIa and plasma kallikrein. SOLUTION : The present invention provides compounds represented by formula (I), where all the variable groups are as defined herein, or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT |
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