| 专利名称 | BENZO-FUSED HETEROCYCLIC DERIVATIVES USEFUL AS AGONISTS OF GPR120 | ||
| 申请号 | JP2019019370 | 申请日 | |
| 公开(公告)号 | JP2019094341A | 公开(公告)日 | |
| 申请(专利权)人 | JANSSEN PHARMACEUTICA NV | 发明人 | SUI ZHIHUA; NALIN L SUBASINGHE |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
PROBLEM TO BE SOLVED : To provide agonists of GPR120, useful in the treatment of, such as for example, Type II diabetes mellitus. SOLUTION : There are provided following compounds, agonists of GPR120, such as 3-{4-[(5-Fluoro-2-methyl-1-benzofuran-7-yl)methoxy]-2, 3-dimethylphenyl}propanoic acid. A disorder modulated by the GPR120 receptor is selected from the group consisting of obesity, obesity related disorders, impaired oral glucose tolerance, insulin resistance, Type II diabetes mellitus, metabolic syndrome, metabolic syndrome X, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related cardiovascular disorders. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT |
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