The present invention relates to the field of medicine, and specifically discloses a dispersion process of adapalene gel preparation, which comprises the following steps : pulverizing adapalene raw material to D50 not more than 10μm and D90 not more than 30μm by dry detection; adding methyl p-hydroxybenzoate, 1, 2-propanediol, carbomer 980 and disodium edetate in water, heating and stirring consistently to obtain a matrix in a uniform jelly; adding poloxamer 188, propylene glycol and ethylene glycol phenyl ether in water, stirring and heating to prepare a mixed solution; adding adapalene in the mixed solution prepared, emulsifying at a high speed, then adding to the matrix for thorough stirring; and then adding a triethanolamine aqueous solution for homogenization and stirring. The preparation prepared by the process of the invention has good emulsifying and dispersing effect of adapalene, can be expanded on a large scale, and the industrial promotion prospect is good.