| 专利名称 | SINGLE DOMAIN BINDING MOLECULE | ||
| 申请号 | US16297544 | 申请日 | |
| 公开（公告）号 | US20190194307A1 | 公开（公告）日 | |
| 申请（专利权）人 | The University Court of the University of Aberdeen | 发明人 | Caroline BARELLE; Mischa Roland MULLER; Valarie CALABRO; Jack BIKKER; John STEVEN; Lioudmila TCHISTIAKOVA; Oleg KOVALENKO; Andrea OLLAND |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention provides a single domain specific binding molecule having the structure [in-line-formulae]FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4[/in-line-formulae] in which the Framework Regions FW1, FW2, FW3a, FW3b, and FW4, the Complementarity Determining Regions CDR1 and CDR3, and the Hypervariable Regions HV2, and HV4 have amino acid sequences as defined which provide a high affinity anti-human serum albumin (HSA) binding domain. |
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