专利名称 | NON-ACTIVATED T CELLS EXPRESSING EXOGENOUS VIRUS-SPECIFIC T CELL RECEPTOR (TCR) | ||
申请号 | US16089809 | 申请日 | |
公开(公告)号 | US20190192566A1 | 公开(公告)日 | |
申请(专利权)人 | Lion TCR Pte Ltd | 发明人 | Antonio Bertoletti; Sarene Koh |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to T cells, in particular a non-activated T cell, comprising an exogenous nucleic acid encoding a T cell Receptor (TCR) specific for a virus. An embodiment of the invention is directed to a non-activated (resting) T cell expressing Hepatitis B virus (HBV) envelope s183-191 TCR capable of inhibiting viral replication and which shows reduced expression of perforins and/or granzymes in response to stimulation as compared to an activated T cell expressing the said TCR. Also encompassed are methods for producing such cells, compositions, pharmaceutical compositions and kits comprising such cells and medical uses thereof. |
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