专利名称 | TRIAZINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES | ||
申请号 | RU2016137263 | 申请日 | |
公开(公告)号 | RU2692789C2 | 公开(公告)日 | |
申请(专利权)人 | JAPAN TOBACCO INC | 发明人 | NAGAMORI Hironobu; MITANI Ikuo; YAMASHITA Masaki; HOTTA Takahiro; NAKAGAWA Yuichi; UEDA Masatoshi |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
FIELD : chemistry.SUBSTANCE : invention relates to a compound of formula [I], or a pharmaceutically acceptable salt thereof. In formula [I] X is CH or N, ring Cy is formulaor formula, R5 is (1) halogen, (2) hydroxy, (3) C1-6 alkylsulphanyl, (4) C1-6 alkyl (said C1-6 alkyl is optionally substituted with 1, 2 or 3 substitutes selected from a group consisting of halogen, C6 aryl and C1-6 alkoxy), (5) C3-7 cycloalkyl, (6) -ORd or (7) formula, m1 is equal to 0, 1, 2 or 3 and, when m1 is equal to 2 or 3, each R5 is selected independently from each other. Other radical values are presented in the patent claim. Invention also relates to individual compounds, to a pharmaceutical composition, to an mPGES-1 inhibitor, to a therapeutic or prophylactic agent, to a mPGES-1 inhibition method, to a method of treating or preventing, to use of the compound.EFFECT : technical result is obtaining novel compounds of formula [I], having PGES-1 inhibitor properties.19 cl, 1 dwg, 64 tbl, 34 ex |
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