The invention relates to medicine, in particular to cardiology and nephrology.Summary of the invention consists in that it is determined the patient' s age (V), the duration of cardiovascular disease (DBCV) and the presence of rhythm disturbances in the anamnesis (TR), is conducted the clinical and paraclinical examination with the determination of the severity of heart failure (IC) and the presence of ischemic cardiopathy (CPI), the level of N-terminal fragment of brain natriuretic peptide (NTproBNP) precursor, the serum level of triglycerides (TRIG) and serum thyrotrophic hormone (TSH), and the discriminant function (F) is calculated by the formula : F = - 16, 775 + 0.111 ?V + 0.145 ?NTproBNP + 2.205 ?TRIG + 1.413 ?IC + 1.693 ?TR + 0.499 ?CPI + 0.040 ?DBCV + 0.082 ?TSH, in the case when F > 0 is confirmed the diagnosis or predicted an increased risk of cardiorenal syndrome, and F < 0 - is excluded the diagnosis or predicted a low risk of cardiorenal syndrome.