A real estate unit in accordance with a particular embodiment of the present technology includes an interior space within a commercial building, and a reusable bathroom removably disposed within the commercial building. The commercial building can include a storefront between the interior space and an outdoor area. The real estate unit can further include reusable wall components removably disposed within the commercial building. For example, the interior space can be within a compartment at least partially defined by the reusable wall components. In at least some cases, the interior space is a purpose-built retail, office, and/or restaurant space. The real estate unit can be a lodging unit, a rentable residential unit, a rentable office unit, and/or a rentable assembly unit.