A real estate unit in accordance with a particular embodiment of the present technology includes an interior space within a commercial building, and a reusable bathroom removably disposed within the commercial building. The commercial building can include a wall between the interior space and an outdoor area. The wall can include an opening having a width within a range from two meters to seven meters. The real estate unit can further include a reusable barrier stationarily and removably disposed between the interior space and the outdoor area. A primary egress path from the interior space to the outdoor area can extend through the opening and through the reusable barrier. In at least some cases, the interior space is a purpose-built loading, storage, parking, and/or vehicle-servicing space. The real estate unit can be a lodging unit, a rentable residential unit, a rentable office unit, and/or a rentable assembly unit.