A real estate unit in accordance with a particular embodiment of the present technology includes an interior space at the ground floor of a commercial building. The interior space can have a purpose-built use (e.g., retail, warehouse, school, garage, etc.) and can be reversibly retrofitted to accommodate an alternative use (e.g., lodging, residential, office, assembly, etc.). The real estate unit can include reusable components (e.g., bathroom, wall, barrier, etc.) well suited for rapid deployment, removal, and redeployment. Use of these components can allow revenue from operating the real estate unit to exceed costs associated within transitioning the interior space from the purpose-built use to the alternative use even if the real estate unit is only operated for a short period of time. Furthermore, capital embodied in the components can be readily relocatable in response to long-term and short-term (e.g., seasonal) changes in demand.