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专利概况
专利名称 INHIBITORS OF BETA SECRETASE
申请号 US16489885 申请日
公开(公告)号 US20200010482A1 公开(公告)日
申请(专利权)人 Janssen Pharmaceutica NV 发明人 Ann Marleen Vos; Daniel Oehlrich; Henricus Jacobus Maria Gijsen; Karl Shawn Watts; Sathesh Pangala Bhat; Frans Maria Alfons Van den Keybus
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to tricyclic inhibitors of beta-secretase having the structure shown in Formula (I) and (II)and the tautomers and the stereoisomeric forms thereof, wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer' s disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down' s syndrome, dementia associated with stroke, dementia associated with Parkinson' s disease, dementia associated with beta-amyloid, age-related macular degeneration, type 2 diabetes and other metabolic disorders.

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