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专利概况
专利名称 3, 4 - [...] derivatives, and its manufacturing method and applications
申请号 JP2019523621 申请日
公开(公告)号 JP2020500177A 公开(公告)日
申请(专利权)人 JIANGSU HENGRUI MEDICINE CO LTD; SHANGHAI HENGRUI PHARMACEUTICAL CO LTD 发明人 ヤン、ファンロン; ジャン、リン; シェン、グアンユエン; フア、フォン; タオ、ウェイカン
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to a 3, 4-bipyridyl pyrazole derivative, and a preparation method therefor and a medical application thereof. Specifically, the present invention relates to a new 3, 4-bipyridyl pyrazole derivative as shown in formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, a use of the derivative as a therapeutic agent, in particular as a TGF-β inhibitor, and a use of the derivative in the preparation of a drug which treats, prevents or reduces cancer mediated by TGF-β overexpression. The substituents in formula (I) have the same definitions as in the description.

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