专利名称 | NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES | ||
申请号 | EP15866163 | 申请日 | |
公开(公告)号 | EP3226689B1 | 公开(公告)日 | |
申请(专利权)人 | Merck Sharp Dohme Corp | 发明人 | FISCHER Christian; BOGEN Stephane L; CHILDERS Matthew L; LLINAS Francesc Xavier Fradera; ELLIS J Michael; ESPOSITE Sara; HOFFMAN Dawn M; HUANG Chunhui; KATTAR Solomon; KIM Alexander J; LAMPE John W; MACHACEK Michelle R; MCMASTERS Daniel R; PARKER Dann L Jr; REUTERSHAN Michael; SCIAMMETTA Nunzio; SHAO Pengcheng P; SLOMAN David L; SUN Wanying; UJJAINWALLA Feroze; WU Zhicai |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of : (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers. |
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