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专利概况
专利名称 PAN-EBOLAVIRUS NEUTRALIZING HUMAN ANTIBODIES AND METHODS OF USE THEREFOR
申请号 WOUS19041349 申请日
公开(公告)号 WO2020014443A1 公开(公告)日
申请(专利权)人 VANDERBILT UNIVERSITY; BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM 发明人 CROWE Jr James E; GILCHUK Pavlo; BUKREYEV Alexander
专利来源 国家知识产权局 转化方式
摘要

The present disclosure is directed to human antibodies binding to and neutralizing ebolavirus and methods for use thereof. A further embodiment involves a monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences. In yet another embodiment, there is provided a hybridoma or engineered cell encoding an antibody or antibody fragment. An additional embodiment comprises a vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences. In still a further embodiment, there is provided a method of protecting the health of a placenta and/or fetus of a pregnant a subject infected with or at risk of infection with ebolavirus comprising delivering to said subject the antibody or antibody fragment.

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