The present invention relates to an oral immediate release pharmaceutical composition in a single unit dosage form comprising flurbiprofen or a pharmaceutically acceptable salt thereof and a H2 receptor antagonist as a gastro protective agent, wherein H2 receptor antagonist is present in an amount of from 5 to 80% by weight of flurbiprofen. The present invention is also about an oral immediate release pharmaceutical composition in a single unit dosage form comprising flurbiprofen or a pharmaceutically acceptable salt thereof, an H2 receptor antagonist, or a pharmaceutically acceptable salt thereof, and a carbonate wherein the H2 receptor antagonist is present in an amount between 10 and 80% by weight based on the weight of flurbiprofen.