FIELD : pharmaceutics.SUBSTANCE : invention refers to pharmaceutical, food and processing industries, namely to a method for producing a complex of bioflavonoids from defatted sea-buckthorn extraction cake. Method for producing a complex of bioflavonoids from defatted sea-buckthorn extraction cake method involves extraction of polyphenolic substances from extraction cake with ethyl alcohol, followed by removing the solvent from the extract, diluting the vacuum concentrate with water at ratio of 1 : 3, filtering and drying the precipitated complex of bioflavonoids.EFFECT : method described above simplifies the technology of obtaining and increases output of bioflavonoids by 13?%.1 cl, 1 tbl, 1 ex