| 专利名称 | CREATING CONTROLLED RELEASE PROFILE OF DRUG SUBSTANCE USING LIPOSOMAL COMPOSITION IN AQUEOUS AND ANHYDROUS SOLUTIONS | ||
| 申请号 | RU2015135629 | 申请日 | |
| 公开(公告)号 | RU2712157C2 | 公开(公告)日 | |
| 申请(专利权)人 | TAJVAN LIPOSOM KOMPANI ELTEDE | 发明人 | KAN PEI; TSENG YUN LONG; OU HAN CHUN |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
FIELD : medicine; pharmaceuticals.SUBSTANCE : group of inventions refers to pharmaceutical industry, in particular to embodiments of a pharmaceutical composition for inhibiting growth of cancer cells. In one embodiment, the composition includes a component which forms a particle selected from a phospholipid and a mixture of at least one phospholipid and cholesterol; 0.1–10 mM dextran sulphate ion or its pharmaceutically acceptable salt; 100–500 mM ammonium sulphate; amphipathic therapeutic agent or its pharmaceutically acceptable salt. In another embodiment of the composition, the amount of ammonium sulphate is 150–450 mM, and the amphipathic therapeutic agent is a vinca roseacola alkaloid. Also disclosed are : a liposome for delivering an amphipathic therapeutic agent and a method of inhibiting growth of cancer cells by administering an effective amount of said pharmaceutical composition.EFFECT : group of inventions provides optimal therapeutic effectiveness and reduced toxic effect on skin.16 cl, 4 dwg, 11 tbl, 10 ex |
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