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专利概况
专利名称 METHODS AND INTERMEDIATES IN PRODUCING C5aR ANTAGONISTS
申请号 RU2017114960 申请日
公开(公告)号 RU2712233C2 公开(公告)日
申请(专利权)人 CHEMOCENTRYX INC 发明人 ZHANG PENGLIE; TANAKA HIROKO; PUNNA SREENIVAS; POWERS JAY; LUI REBECCA; KRASINSKI ANTONI; KALISIAK JAROSLAW; FAN PINGCHEN
专利来源 国家知识产权局 转化方式
摘要

FIELD : chemistry.SUBSTANCE : invention relates to intermediate compounds of formula (i-3) and (ii-4), in which R is selected from a group consisting of H, C1-8 alkyl, aryl and aryl-C1-4 alkyl, R1 is Cl or CF3, or salt thereof. Invention also relates to a method of producing a compound of formula (I), where R1 is Cl or CF3, R2 is F or Cl and R3 is H or CH3 or to its salt. (i-3)…… (ii-4) (I)EFFECT : technical result is obtaining novel compounds which can be used in producing the final compound of formula (I), which can be used in medicine as C5aR antagonists.35 cl, 4 dwg, 4 ex

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