专利名称 | PYRROLO[2, 3-D]PYRIMIDINE COMPOUND OR SALT THEREOF | ||
申请号 | RU2018103360 | 申请日 | |
公开(公告)号 | RU2712269C2 | 公开(公告)日 | |
申请(专利权)人 | ТАЙХО ФАРМАСЬЮТИКАЛ КО ЛТД; TAIHO PHARMACEUTICAL CO LTD | 发明人 | НАКАМУРА Масаюки; НАКАМУРА МасаюкиNAKAMURA Masayuki; ЯМАНАКА Хироёси; ЯМАНАКА ХироёсиYAMANAKA Hiroyoshi; МИЦУЯ Морихиро; МИЦУЯ МорихироMITSUYA Morihiro; ХАРАДА Такафуми; ХАРАДА ТакафумиHARADA Takafumi |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
FIELD : medicine; pharmaceuticals.SUBSTANCE : invention relates to a new compound of formula (I) or a pharmaceutically acceptable salt thereof. Compound has the properties of a selective JAK3 inhibitor, exhibits high activity in suppressing the growth of human peripheral blood monocytes and oral absorption, and also exhibits activity when inhibiting IFN-γ in vivo. In general formula (I)X is -CH = CH-, sulphur atom or oxygen atom; and n denotes integer from 0 to 2.EFFECT : compound can be used for treating diseases involving JAK3, where the disease involving JAK3 is selected from a group consisting of psoriasis, graft versus host, multiple sclerosis, inflammatory bowel disease, systemic lupus erythematosus and rheumatoid arthritis.16 cl, 2 dwg, 5 tbl, 31 ex |
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