Provided in the present invention are a metformin compound composition and the use thereof. The active ingredients of the compound composition include metformin, omega-3 fatty acids, statins and vitamins. A combination of all or some of these active ingredients can be prepared as a single dosage form for the prevention or treatment of special diseases or that is generally health-enhancing. Preventable and treatable diseases include diseases of the cardiovascular system, nervous system diseases, cancers, diabetes, autoimmune diseases, and other diseases that can be treated with this dosage form.