The present invention provides a deutero-substituted polycyclic pyridone compound and a prodrug thereof, and a composition containing the compound, and use thereof. The deutero-substituted polycyclic pyridone compound is a compound represented by formula (I), or is a tautomer thereof, a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a hydrate, or a solvent compound. The compound and composition of the present invention have cap-dependent endonuclease inhibitory activity, and have a better pharmacokinetic property.