To provide a method for separating and purifying 2-chloro-3 -trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like. [Means for Solution] A method including : 1) in the process of producing chioro -trifluoromethylpyridine compounds by allowing a -methylpyridine compound to react with chlorine and hydrogen fluoride in a reaction apparatus, allowing a j3-trifluoromethylpyridine compound to react with chlorine in a reaction apparatus, or allowing a chlorotrichloromethy1pyridine compound to react with hydrogen fluoride in a reaction apparatus, 2) fractionating a liquid mixture containing chloro - trifluoromethylpyridine compounds from the reaction apparatus, and 3) separating and puriftting 2-chloro-3-trifluoromethylpyridine from the liquid mixture. [Selected Figure] Nil