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专利概况
专利名称 2-(SUBSTITUTED BENZENE MATRIX) AROMATIC FORMATE FTO INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF
申请号 EP18760913 申请日
公开(公告)号 EP3590920A1 公开(公告)日
申请(专利权)人 Shanghai Institute of Materia Medica Chinese Academy of Sciences 发明人 YANG Caiguang; HUANG Yue; DONG Ze; ZHANG Tao; XU Hongjiao
专利来源 国家知识产权局 转化方式
摘要

The invention provides 2-(substituted phenylhetero) aromatic formate FTO inhibitor, a preparation method thereof, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted phenylhetero) aromatic formate compound represented by the following formula (I), and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, which can be used as an FTO targeting inhibitor for treating diseases associated with FTO targets, including obesity, metabolic syndrome (MS), type 2 diabetes (T2D), Alzheimer' s diseases, and cancers such as breast cancers, small-cell lung cancers, human bone marrow rhabdomyosarcoma, pancreatic cancer, malignant glioblastoma and the like.

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