专利名称 | 2-(SUBSTITUTED BENZENE MATRIX) AROMATIC FORMATE FTO INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF | ||
申请号 | EP18760913 | 申请日 | |
公开(公告)号 | EP3590920A1 | 公开(公告)日 | |
申请(专利权)人 | Shanghai Institute of Materia Medica Chinese Academy of Sciences | 发明人 | YANG Caiguang; HUANG Yue; DONG Ze; ZHANG Tao; XU Hongjiao |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The invention provides 2-(substituted phenylhetero) aromatic formate FTO inhibitor, a preparation method thereof, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted phenylhetero) aromatic formate compound represented by the following formula (I), and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, which can be used as an FTO targeting inhibitor for treating diseases associated with FTO targets, including obesity, metabolic syndrome (MS), type 2 diabetes (T2D), Alzheimer' s diseases, and cancers such as breast cancers, small-cell lung cancers, human bone marrow rhabdomyosarcoma, pancreatic cancer, malignant glioblastoma and the like. |
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