A tobacco and smoke-less product comprises a first quantity of a first compound in a form suitable to release in-vivo in a human body a dose of a nicotinic agonist tolerable by the human body and sufficient to provide a sensation similar to that of nicotine released into the body by smoking tobacco. The product further comprises a second quantity of a second compound in a form suitable to release in-vivo in the human body a dose of non-psychoactive cannabinoid tolerable by the human body which reduces the desire to smoke tobacco. The product can be e.g. an epicurean product or a medical product, e.g. to treat smoking addition. The product can be provided in a kit of two or more products, such as to release different doses of the nicotinic agonist.