专利名称 | PAN-EBOLAVIRUS NEUTRALIZING HUMAN ANTIBODIES AND METHODS OF USE THEREFOR | ||
申请号 | WOUS19041349 | 申请日 | |
公开(公告)号 | WO2020014443A1 | 公开(公告)日 | |
申请(专利权)人 | VANDERBILT UNIVERSITY; BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM | 发明人 | CROWE Jr James E; GILCHUK Pavlo; BUKREYEV Alexander |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present disclosure is directed to human antibodies binding to and neutralizing ebolavirus and methods for use thereof. A further embodiment involves a monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences. In yet another embodiment, there is provided a hybridoma or engineered cell encoding an antibody or antibody fragment. An additional embodiment comprises a vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences. In still a further embodiment, there is provided a method of protecting the health of a placenta and/or fetus of a pregnant a subject infected with or at risk of infection with ebolavirus comprising delivering to said subject the antibody or antibody fragment. |
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