The present invention relates to compositions comprising one or more glucocorticoid(s)used in the topical treatment of autoimmune gastritisby delivering an effective amount of the glucocorticoid(s) to the topical area to be treated using a gastroretentive drug delivery system that releases the glucocorticoid(s) in a timely and locally controlled manner. Particularly, the topical area to be treated comprises or is the stomach mucosa, preferably the corpus and/or fundus of the stomach and the preferred glucocorticoid is budesonide.